Principle of Ultrasound-Assisted Extraction (UAE)

Polysaccharides are macromolecules composed of multiple monosaccharide units connected by glycosidic bonds, and they are distributed widely in living organisms. These compounds exhibit diverse physiological activities and functions, like immunomodulation, antioxidant effects, and potential antitumor properties. However, traditional approaches suffer from issues like time-consuming with low productivity. For the past few years, the application of UAE on polysaccharides has garnered significant attention due to its high productivity, safety, and environmental friendliness. This technique utilizes the mechanical vibrations and thermal effects generated with ultrasound to enhance the mixing, diffusion, and reactions within substances. In this process, ultrasound disrupts cell walls and prompts the release of molecules trapped inside cells. Additionally, it increases the contact area between the sugar solution and solvent, thereby improving dissolution rates. Nowadays, the study of polysaccharides by applying UAE has yielded encouraging research results.

UAE Service at CD BioGlyco

CD BioGlyco is equipped with high-performance equipment and skilled technicians to provide reliable UAE service. The process of our service is as follows:

• Preparation of Raw Materials and Extraction Solution

Select the appropriate polysaccharide source material and chop or grind it to the appropriate particle size as needed. For plant-based polysaccharides, pre-treatment steps like removing impurities and coarse separation can be carried out first. Subsequently, a suitable extraction solution is selected according to the characteristics of the sample.

• Extraction Process 

Appropriate amounts of adjuvants such as acidifiers or enzymes are added to the extraction solution to facilitate the extraction. Mix the sample thoroughly with the extraction solution to ensure that the polysaccharide is in full contact with the solvent. Subsequently, the mixed solution is placed in the ultrasonic extraction device. Depending on the properties of the samples, set the parameters of the ultrasonic equipment. Typically, we start with low initial power and frequency and gradually increase it to achieve the best results.

• Concentration and Purification Processing 

The extract is centrifuged, filtered, or precipitated to separate the extract from the residue. The final product is then obtained after concentration, purification, and drying.

Fig.1 Classification of operating modes for UAE of polysaccharide. (CD BioGlyco)

Applications

• Techniques for polysaccharide extraction can be used to extract polysaccharides from plants, which often exhibit pharmacological activities such as anti-inflammatory, anti-tumor, and immunomodulatory activities.
• Polysaccharides are often used in cosmetics and skincare products for their moisturizing, antioxidant, and skin-repairing properties.
• Polysaccharides are used in the preparation of drug-sustained release systems for controlling the rate of drug release and enhancing efficacy.

Advantages of Us

• UAE reduces thermal degradation and oxidative reactions of polysaccharides and helps to maintain their biological activity and functionality.
• UAE greatly reduces the extraction time and improves the extraction efficiency of polysaccharides.
• We are oriented to client satisfaction and provide all-round, thoughtful after-sales support for our clients. 

At CD BioGlyco, our team has accumulated profound technical strength in the field of Polysaccharide Extraction, and we will utilize advanced ultrasound technology to provide clients with UAE services. If you are interested in our services, please contact us for more details.

• Hot Water Extraction Service
• Acid-Base Extraction Service
• Microwave Assisted Extraction Service
• Enzymatic Extraction Service
• Supercritical Fluid Extraction Service