Feasibility of Chemical Modification

GLs (GLs) are a class of biosurfactants widely used in detergents, cosmetics, etc., with special biological properties and surface activity. Currently, industrial GLs are mainly obtained by microbial fermentation. However, the structure of GLs obtained by microbial fermentation is relatively fixed and cannot produce novel GLs. So it is necessary to add some modification methods in the synthesis process of GLs to change the structure and properties of GLs.

GLs are amphiphilic, i.e. hydrophilic and hydrophobic. They contain certain reaction sites. Therefore, the synthesis process of GLs can be influenced by chemical modification to generate new modified GL derivatives and improve their added value. The chemical modification changes the structure of GLs and establishes a link between structure and function, thus expanding the application scope of GLs. It is found that the GL derivatives generated by chemical modification can increase their water solubility and improve their surface tension and emulsification properties.

Tab.1 The SL derivatives from selected papers and their applications. (Pala, et al., 2023)

We Are the Best Choice

CD BioGlyco investigates chemical modification methods to increase the structural variability of GLs based on traditional microbial fermentation processes. Currently, our chemical modifications are mainly targeted with the modification of sophorolipid (SL). The chemically modified derivatives have better antiviral and antibacterial abilities and their surface tension properties are improved compared with the conventional SLs.

• SL chemical modification services

Our chemical modifications during GL synthesis include the following three methods:

Fig.1 Type of SL chemical modification. (CD BioGlyco)

• Lipid tail modification service for SL

CD BioGlyco improves the properties of SL by modifying the carboxyl terminus of the SL lipid chain. Synthesize SL derivatives, such as SL-ester derivatives and SL amides, by amidating or esterifying the carboxyl terminus. We will compare the emulsification properties, surface tension, etc., of SL derivatives with natural SL. We also further chemically modify the SL derivatives to generate new derivatives.

• SL tail double bond modification service

The double bonds in the lipid tails of SL are more sensitive and can be targeted by chemical modification to synthesize new SL derivatives. We generate short-chain SLs or SLs of different chain lengths by alkaline hydrolysis. We also oxidatively cleave double bonds on SLs by other methods to generate SL-aldehydes, SL amines, quaternary amine SLs, and others.

• SL head group modification service

We enhance the properties of SL by generating its couplings with other compounds. For example, SL-amino acid conjugates synthesized after modification have better surfactant properties and water solubility.

• SL production services

SL is an environmentally friendly, non-toxic, and non-polluting biosurfactant with a wide range of applications. As a comprehensive supplier in the field of new bio-materials, CD BioGlyco offers SL with quality assurance.

Applications

• GL has a high potential for application in the food industry. GL chemical modification methods are used to improve the properties of GL and ultimately enhance the quality and safety of various food products.
• GL chemical modification methods are used to synthesize GL with novel structures. The synthesized novel GLs have an important role in drug development.
• GL is an environmentally friendly biosurfactant. The GLs generated by chemical modification are used to study their potential applications in oil pollution control, heavy metal pollution control, etc.

Advantages

• We specialize in the modification of SL by various chemical reactions, with a wide range of chemical modification methods. All modification methods are research-based.
• Our GL products have good surface activity, very low CMC concentration, and an inhibitory effect on some bacteria.
• GL modification technology helps researchers to synthesize new types of GLs, thereby improving the properties of GLs and their effectiveness in drug penetration, soil remediation, etc.

CD BioGlyco not only produces natural SL but also researches the application of chemical modification in SL production. We have a professional research team that develops detailed modification strategies according to customer needs. Besides chemical modification, we also provide Natural Extraction-based Carbohydrate Derivative Manufacture Service and Chemical Syntheis-based Carbohydrate Derivative Manufacture Service. If you are interested in obtaining new SL derivatives, please feel free to contact us.

• Bacterial Fermentation Process-based Glycolipid Manufacture Service
• Yeast Fermentation Process-based Glycolipid Manufacture Service
• Enzymatic Post-Treatment-based Glycolipid Manufacture Service