Structure of Schizophyllan

Schizophyllan is a naturally water-soluble exopolysaccharide synthesized by the basidiomycete Schizophyllum commune. It is a homoglycan with a beta-(1,3)-linked backbone, connecting a beta-(1,6)-linked glucose side chain approximately every three residues. Schizophyllan has a rod-like triple helix structure in water, and molecules with relative molecular mass greater than 100,000 have good biological activity.

Fig.1 Repeating tetra-saccharide monomer and triple helix of schizophyllan. (Kony, et al., 2007)

Biological Activities of Schizophyllan

Schizophyllan has remarkable anti-tumor and immunomodulating activities, which can regulate skin immunity, promote skin cell proliferation and collagen synthesis, delay senescence, clear free radicals, resist ultraviolet rays, repair sun damage, and resist inflammation. It acts as a biological response modifier and non-specific stimulator of the immune system, with the ability to enhance vaccines and anti-tumor therapies. Interestingly, schizophyllan is similar to Lentinan in composition and biological activity, sharing analogical immunomodulatory effects and anti-tumor mechanisms with lentinan.

Schizophyllan Manufacture Service

Extensive research on schizophyllan has led to a wide range of medicinal applications. At CD BioGlyco, customers will receive include:

Fig.2 Schizophyllan manufacture service. (CD BioGlyco)

• Extraction service

CD BioGlyco provides conventional methods such as Hot Water Extraction, Enzymatic Extraction, dilute alkali-based extraction, etc. as well as novel processes such as Ultrasound Assisted Extraction, Microwave Assisted Extraction, flash extraction, etc. Through the combination of new technologies and traditional methods, extraction efficiency can be effectively improved, and time and cost can be saved.

• Purification service

CD BioGlyco has various purification strategies including decolorization, deproteinization, dialysis, and column chromatography.

• The commonly used decolorization methods include activated carbon adsorption, silica gel adsorption, and clay adsorption.
• The deproteinization methods include the Sevage process, trichloroacetic acid process, protease elution, and isoelectric point-based elution.
• Further purification: Gel Column Chromatography, Ion Exchange Chromatography, cellulose column chromatography, Salt Fractionation-based Purification, dialysis, etc. are available.
• Schizophyllan modification service

To expand the commercial use of schizophyllan and further research in the pharmaceutical field, schizophyllan modification is sometimes required. CD BioGlyco provides modification services such as enzymatic modification, as well as various chemical modification methods (carboxylation and carboxymethylation, phosphoric acid esterification, sulfate esterification, etc.). We also offer a range of schizophyllan complex synthesis services to support the research and application of schizophyllan in drug delivery.

Applications

• Used in Oil recovery
• Thickening agent for cosmetic lotion
• Oxygen-impervious film for food preservation
• High-value pharmaceutical applications: immunomodulators, drug delivery carriers, antitumor therapies

Highlights

• Advanced extraction technology and mild extraction conditions
• Multi-stage purification technology: high purity of the product

CD BioGlyco integrates diversified technologies to provide clients with the most efficient, economical manufacture strategy. We are committed to offering the most satisfactory glucan manufacture service. If you are interested in our One-Stop Solution for Carbohydrate Manufacture, please feel free to contact us.

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