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Monosaccharide Conversion
More than a century ago, the mutual conversion of aldose and the homologous ketose was discovered. The discovery expanded the application of sugar in various fields and promoted the research of different conversion technologies. For example, the isomerization of glucose to fructose to produce high fructose corn syrup (HFCS) is a large-scale catalytic process in industry.
Fig.1 How is HFCS made? (CD BioGlyco)
In addition, rare sugars, which exist in nature but in very small amounts, play an indispensable role in the field of diet and medicine. They can be used as food additives to improve food properties as well as to modify drugs or active substances to optimize their functions. Rare sugars are almost always obtained from cheap and naturally subsistent monosaccharides through chemical synthesis, microbial fermentation, and biocatalysis.
Our Services
CD BioGlyco has extensive expertise in monosaccharide manufacture. In addition to Enzymatic/Microbial Isomerization Service, we also offer alternative chemical strategies to obtain desired monosaccharide products for our customers. At CD BioGlyco, you will be able to achieve the conversion of one monosaccharide and another monosaccharide with different structure and the same number of carbon atoms (for example, from glucose to fructose), the conversion of one monosaccharide and the sugar alcohol with the same number of carbon atoms (for example, from xylose to xylitol), and the conversion of one monosaccharide and another monosaccharide with different carbon atoms (for example, from glucose to arabinose).
In this method, acid/base catalysts are generally used, and other novel catalysts such as basic amino acids are also reported. According to the different technologies, catalytic isomerization can be divided into homogeneous catalysis and heterogeneous catalysis, both of which can realize the mutual conversion of monosaccharides with different configurations.
Fig.2 Mechanism of the catalytic isomerization of glucose to fructose catalyzed by basic amino acid. (CD BioGlyco, 2023, recomposed from Zhou, et al., 2017)
This method can realize the conversion of monosaccharides with different carbon atoms, involving the increased reactions of aldose and the decreased reactions of aldose. It is a common strategy in the field of monosaccharide synthesis, and many classical reactions have been reported and applied.
Fig.3 Mechanism of the chemical conversion of D-glucose to D-arabinose. (Luo, et al., 2014)
With the chemical strategies mentioned above, customers easily access difficult-to-extract rare sugars or sugar alcohols, for use in food, medicine, and other industries.
Applications
- HFCS production
- Rare monosaccharides production
- Xylitol production
- Development of food and medical industries
Highlights
- Scientific and credible chemical conversion
- Affordable rare sugar and sugar alcohol production process
- Mass production capacity
- Controlled, optimized production conditions
CD BioGlyco's philosophy is to work with you in good faith and ensure the successful delivery of the products. We also provide other Monosaccharide Manufacture Technologies. If you would like to know more about our One-Stop Solution for Carbohydrate Manufacture, please contact us today.
References
- Zhou, Y.B.; et al. Recent advance in isomerization of glucose. Industrial Catalysis. 2017, 25(4): 17-22.
- Luo, X.T.; et al. Recent advanced in the strategy for synthesis of rare monosaccharides and derivate sugar alcohol. China Food Additives. 2014, 8: 150-157.
For research use only. Not
intended for any clinical use.
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