The Structure of Shitake Beta-Glucan

The primary structure of shitake beta-glucan includes a β (1,3) bond-linked glucose backbone and a side chain connecting the backbone via a 6-C branch. Specifically, the side chain is a glucose-low polymer connected by the bond β (1,6) and β (1,3) bonds. The molecular weight of the β-glucan varies between 300 and 800 kDa, with an average of about 500 kDa. Shitake β-glucan has a triple helix stereostructure, and the immune activity disappears when this three-dimensional structure is destroyed by urea and DMSO. Shitake β-Glucan is the most effective bioactive ingredient isolated from the fruiting body of shiitake mushrooms, with antitumor, antioxidant, and other pharmacological effects. A large amount of evidence β-glucan activates immune cells such as macrophages, natural killer cells, etc., to stimulate the immune system and promote health.

Fig.1 Structure of β-glucan of shitake. (Vetter, et al., 2023)

Shitake Beta-Glucan Manufacture Service at CD BioGlyco

CD BioGlyco is experienced in Glucan manufacturing, and we have developed different protocols to meet the needs of customers for research or industrial use. We use different methods for extraction, including water extraction, acid extraction, enzymatic method ultrasound, etc. The extraction method is adjusted according to the demand, and the salary is constantly optimized to ensure the maximum output. Each step of the process extraction was strictly controlled. The extraction process includes pretreatment, extraction, concentration, precipitation, and drying. In addition, our company offers detailed analytical services, such as gas chromatography (GC) profile, Fourier transform infrared spectrometer (FT-IR), nuclear magnetic resonance (NMR), etc.

Fig.2 Extraction process of the shitake beta-glucan. (CD BioGlyco)

Applications

• Shitake beta-glucan reduces the occurrence of inflammation and improves the survival rate in cold-water fish farming.
• Shitake beta-glucan products improve the body's immune functions as drugs add ingredients.
• Shitake beta-glucan products promote wound healing and can be used as a skin dress.
• In the food industry, shitake beta-glucan can be used for the production of functional food products.
• Shitake beta-glucan products have remarkable effects in anti-inflammation and antioxidant aspects.

Advantages

• 10 processing procedures are involved.
• The manufacture of shitake beta-glucan with high purity.
• The process of shitake beta-glucan uses less water, and it is safe and pollution-free.
• Shitake beta-glucan product powder is without adhesion.

CD BioGlyco has rich experience in the field of Carbohydrate Manufacture. Moreover, we provide high-quality Polysaccharide Extraction Services and Polysaccharide Purification Services to customers around the world and are praised by customers in many countries. If you would like to learn more about the manufacturing of polysaccharides, please do not hesitate to contact us.

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