Characteristics of Enzymatic and Synthetic Carbohydrate Derivatives

Carbohydrate derivatives contain mainly C, H, and O atoms in their structure. Carbohydrate derivatives include monosaccharides, disaccharides, and polysaccharides. Carbohydrate derivatives of the polysaccharide type are composed of monosaccharides linked by glycosidic bonds. Therefore, the structural diversity of monosaccharides and the stereoselectivity of glycosidic bonds give polysaccharide-type carbohydrate derivatives complex structures. The main principle of enzymatic synthesis of polysaccharide-based carbohydrate derivatives is the synthesis of the target substance by enzyme-catalyzed polymers. This method allows obtaining carbohydrate derivatives with specific functions such as emulsification, solubilization, descaling, and targeted drug delivery. In addition, enzymatic synthesis of carbohydrate derivatives does not pollute the environment, which is in line with the concept of "green chemistry".

Our Technologies

Enzymes have high catalytic activity, are reusable and non-toxic. Moreover, reactions catalyzed by enzymes are highly selective and allow for more precise control of the structure of the product.

CD BioGlyco comprehensively investigates the enzymatic synthesis of complex carbohydrate derivatives. Specifically, it encompasses the following technologies:

• Enzyme immobilization

At CD BioGlyco, we utilize metal chelators to immobilize the enzyme to a specific material and then proceed to catalyze the reaction. This method enhances the stability of the enzyme and enables repeated use of the enzyme.

• Directed mutagenesis of enzymes

To optimize enzyme-catalyzed reactions for the preparation of carbohydrate derivatives, we also offer enzyme mutation techniques. We utilize gene mutation as well as DNA recombination techniques to modify enzymes to get the best catalytic effect.

• Combination of enzymatic and chemical methods

To capitalize on the advantages of the Chemical Synthesis of Complex Carbohydrate Derivatives, we offer a combined chemical-enzymatic technique for the production of carbohydrate derivatives.

There are several different sequences of chemical-enzymatic synthesis reactions:

• A substrate analog is synthesized through a chemical reaction followed by an enzyme-catalyzed synthesis.
• The enzyme-catalyzed reaction is followed by chemical diversification.

Synthetic reactions with different sequences are capable of efficiently preparing complex carbohydrate derivatives with branched or grafted structures.

Fig.1 Technologies we offer for the enzymatic synthesis of carbohydrates. (CD BioGlyco)

Applications

• Carbohydrate derivatives can be used in the development of food additives.
• In the pharmaceutical field, carbohydrate derivatives are used to develop drugs with physiological activity. Examples include drugs that lower blood sugar and modulate immunity.

Advantages

• Our enzyme catalysis technology helps to study the biological functions of enzymes.
• Our technology for the production of carbohydrate derivatives helps to explore the physiological functions of carbohydrate derivatives.

CD BioGlyco has considerable experimental experience in the production of carbohydrate derivatives. We have advanced experimental equipment and experienced researchers to guarantee experimental results for our customers. Customers can contact our staff directly and we will reply promptly. If you are interested in our services, please contact us for more details.

• Natural Extraction-based Carbohydrate Derivative Manufacture Service
• Chemical Synthesis-based Carbohydrate Derivative Manufacture Service
• Microbial Fermentation-based Carbohydrate Derivative Manufacture Service