Chemical Conversion for Rare Sugar

In the carbohydrate family, monosaccharides are one of the most important members, and they have obvious commonalities and outstanding personalities, which have aroused the great interest of researchers. D-glucose, D-fructose, D-xylose, etc. are whispered and exist in large quantities in nature, but other monosaccharides such as D-allulose are extremely rare in nature. Obtaining these rare sugars and their derivatives such as sugar alcohols requires artificial means.

Fig.1 Chemical structures of some rare sugars. (PubChem)

Chemical conversion is a widely studied and rapidly developed method. Chemical reactions are used to produce the desired and less readily available monosaccharides and the corresponding sugar alcohols based on the economical and abundant monosaccharides, which are of vital importance in the food and medicine industries.

Our Services

CD BioGlyco has comprehensive technologies in monosaccharide production. In our Monosaccharide Manufacture Service via chemical conversion, we offer a variety of chemical reaction strategies to achieve the conversion between monosaccharides and sugar alcohols, as well as the increase and degradation of carbon atoms in monosaccharides to obtain another monosaccharide with different carbon atom numbers on the basis of one monosaccharide. This is a common strategy for the synthesis of rare sugars.

• Redox reaction service

Through redox reaction, the corresponding sugar alcohols will be prepared by high-pressure hydrogenation (H₂) with monosaccharides as the substrates and Raney nickel as the catalyst. At CD BioGlyco, the method is most used to produce xylitol, and it has been continuously improved. The batch hydrogenation process replaces the continuous hydrogenation process, which reduces the consumption of raw materials, greatly reduces the cost, and improves production efficiency.

Fig.2 Redox reaction in xylitol production. (CD BioGlyco)

• Aldose increase reaction service

The method involves the most classical Kiliani-Fisher synthesis reaction, which can produce aldoses that have one more carbon atom than the raw monosaccharides.

Fig.3 Mechanism of Kiliani-Fisher synthesis reaction. (Wikipedia)

• Aldose degradation service

The method is mainly used for the synthesis of rare pentose, tetrose, and corresponding sugar alcohols from cheap and readily available hexose, involving two classical chemical reactions: Wohl degradation and Wohl degradation.

Fig.4 Mechanisms of Wohl degradation reaction (A) and Wohl degradation reaction (B). (Wikipedia)

Based on our chemical conversion strategy, from cheap monosaccharide raw materials, you will obtain high-purity sugar alcohols and rare sugars for use in food additives, pharmaceutical research, or the chemical industry.

Applications

• Sugar alcohol production
• Rare sugar production
• Development of the food and pharmaceutical industries

Highlights

• Science, classical chemical conversion
• Optional monosaccharide production strategies
• Rigorous process and professional technical personnel
• High-quality rare sugars and sugar alcohols

CD BioGlyco is regarded as a strategic partner by many leading companies in the market, and we ensure that we provide scientific and safe manufacturing services. Our expertise and capability run across Monosaccharide, Oligosaccharide, Polysaccharide, Carbohydrate derivative, Glycolipid, and Syrup Manufacture. If you are interested in our technology and products, please contact us.

• Catalytic Isomerization