Beta-Glucan Structure-Function Relationship

β-Glucan is a polysaccharide widely present in microorganisms, mushrooms, and plants of different sources. β-Glucan has different primary structures and conformation. The primary structure type is determined by the degree of glycosidic bonds, branching, and polymerization. The conformation of dextran usually manifests as irregular curling, single helix, or triple helix, and is affected by the primary structure, intermolecular force, temperature, and solvent. β-Glucan of different bacteria because of its different types and numbers of side chain residues on the biological activity of the body is also different. In the past few years, complex mass spectrometry techniques and instrumentation have developed rapidly in the biomedical field. Contemporary glycobiology also benefits from these developments, and the study of glycan structure requires a combination of high-throughput techniques to reliably identify glycan structure. 

Fig.1 The relationship between structure and function of β-glucan. (Du, et al., 2019)

Beta-Glucan Structural Analysis at CD BioGlyco

In a pure polysaccharide, the concentration of reducing glycans, having a free carbonyl group at the reducing ends, represents the quantity of reducing end groups, depending on polymerization degrees (DP) and degree of branching (DB). CD BioGlyco has made significant strides in developing powerful structural tools that can probe even the most complex structural properties. We provide our clients with a range of analysis services in the field of β-glycan structure analysis, including but not limited to the following analysis methods:

Applications

• Beta-glucan structural analysis can be used in disease diagnosis and treatment studies.
• Beta-glucan structural analysis is used to study on structure-effect relationship.

Advantages

• Beta-glucan structural analysis with high-throughput and automated facilities, professional and experienced R & D team.
• CD BioGlyco provides customers with results of precise glycan structure analysis under a systematic and powerful analysis system.
• Deep beta-glucan structural analysis will help the study of glycan macroscopic microscopic particles.

Combining multiple glycobiology platforms, CD BioGlyco provides high-quality services to obtain systematic and accurate experimental data under the operation of well-trained researchers. We are capable of providing efficient and reliable services to accelerate our clients' scientific research by shortening the project time. If you need Beta-Glucan Manufacture, Quantification, Fermentation Profiling, or Vaccine Adjuvants services, please contact us further to introduce the specific service in detail.

• Beta-Glucan Manufacture Service
• Beta-Glucan Quantification Service
• Beta-Glucan Fermentation Profiling Service
• Beta-Glucan Vaccine Adjuvant Development
• DB Analysis
• DP/MW Analysis By SEC
• Linkage Ratio Analysis