Beta-Glucan Manufacture Service
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Characteristics of Beta-Glucan
Beta-glucan is a polysaccharide formed by D-glucopyranose connected by beta-1,3/1,6 or beta-1,3/1,4 glycosidic bonds, which was first discovered by Dr. Pillemer, and further extracted and isolated by Dr. Diluzio. It has excellent physiological activity, and the special bonding mode and the existence of intramolecular hydrogen bonds result in a helical molecular structure, which is easily recognized by the immune system. Beta-glucan is a dietary fiber with high solubility, high stability, and high viscosity, commonly used in functional food production.
Fig.1 Structure of beta-glucan from different sources. (Du, et al., 2019)
Effect of Beta-Glucan
Beta-glucan can activate macrophages and neutrophils, thus increasing the content of leukin, cytokinin, and special antibodies, and comprehensively stimulating the immune system of the body. The regulation of immune system activation by beta-glucan is quite complex. It stimulates the innate immune system as a foreign substance and is recognized as microbe-associated molecular patterns (MAMPs), which have evolved pattern recognition receptors on immune cells that recognize and interact with MAMPs.
Fig.2 Beta-glucan signaling in macrophages. (Alves da Cunha, et al., 2017)
Beta-Glucan Manufacture Service
Beta-glucan plays a pivotal role in various fields. CD BioGlyco has unique insights into polysaccharide research. We offer a variety of beta-glucan manufacture services, including but not limited to the below. Moreover, we offer high-quality Custom Beta-Glucan Manufacture Services.
Oat beta-glucan is a water-soluble polysaccharide derived from the endosperm of oat. It is composed of up to 200,000 glucose units and has a molecular weight range1500-3000 kDa. It has the effect of lowering serum cholesterol and blood glucose.
Curdlan is a water-insoluble microbial exopolysaccharide, which can form heat irreversible gel when heated in water. it can be directly added to food as a food additive.
Lentinan has been applied to various cancer therapies. It regulates the immune system by activating immune cells and enhancing the activity of NK cells, thus inhibiting tumor growth.
Different from common polysaccharides, the molecular chain end of laminarin contains sulfuric acid group, which is connected with polysaccharide through ester bond.
Paramylon is a water-insoluble linear, unbranched beta-(1,3)-D-glucan, which has been applied in food, medicine, and cosmetics. It has considerable biological efficacy in enhancing human immunity.
Zymosan is water-insoluble polysaccharide extracted from the cell wall of Saccharomyces cerevisiae. It is widely used as functional food and reagents for inflammation and immunology research.
Grifolan has strong anti-cancer activity and immunomodulatory effect. In addition, it also has the effect in regulating blood glucose, lipid and cholesterol levels, and lowering blood pressure.
Schizophyllan is a water-soluble homoglycan, and can be used in oil recovery, as a thickening agent for cosmetic emulsions, an oxygen-impervious film for food preservation, and has high-value pharmaceutical applications.
Applications
- Functional food development
- Anti-infection and anti-tumor therapy
- Ingredient of cosmetics
Advantages
- Efficient beta-glucan production process
- Manufacture technologies of beta-glucan from various sources
CD BioGlyco has a great wealth of experience in beta-glucan production, and we provide accurate, and reliable manufacture services to our clients worldwide. If you are interested in our services, please contact us for more information.
References
- Du, B.; et al. A concise review on the molecular structure and function relationship of β-glucan. International Journal of Molecular Sciences. 2019, 20(16): 4032.
- Alves da Cunha, M.A.; et al. Structure and biological functions of d-glucans and their applications. Studies in Natural Products Chemistry. 2017, 53: 309-337.
- Liu, Y.; et al. An overview on natural polysaccharides with antioxidant properties. Current Medicinal Chemistry. 2013, 20(23): 2899-2913.
For research use only. Not
intended for any clinical use.
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