Structure of Laminarian

Laminarin is also known as laminaran or leucosin, and is a water-soluble and branched polysaccharide found in vacuoles within the cells of brown algae. Laminarin is a class of low-molecular-weight storage beta-glucan, consisting of (1,3)-beta-D-glucan with some 6-O-branching in the main chain and some beta-(1,6)-linkages. There are two kinds of Laminarin chains, M type and G type, depending on the reducing end, where M chains end in 1-O-substituted D-mannitol and G chains end in glucose.

Fig.1 Chemical structures of M and G chain of laminarin. (Karuppusamy, et al., 2022)

Fig.2 Antioxidant mechanisms of laminarin. (Karuppusamy, et al., 2022)

Laminarian Manufacture Service

Laminarin has great therapeutic potential and has attracted much attention from the scientific community. CD BioGlyco has a professional, scientifical, and technical team, which has accumulated a lot of experience in laminarin manufacture and has a variety of production strategies to achieve large-scale production of laminarin.

• Traditional extraction strategy

Extraction process: brown algae flour→dissolving in water/mild acid/alkali→centrifuging and gathering supernatant→concentrating and precipitating with ethanol→degreasing and decolorizing→drying→laminarin

• Innovative extraction strategies
• Enzyme-assisted extraction: Destroy the cell wall of brown algae using cell wall carbohydrate hydrolytic enzymes and proteases and release laminarin.
• Microwave-assisted extraction: Microwave has good penetration, and can effectively extract heat-sensitive substances. It can realize the efficient extraction of laminarin.
• Ultrasound-assisted extraction: Destroy cells with mechanical effects and cavitation of ultrasound and accelerate the dissolution of laminarin.
• Purification of laminarin

Strategies including size-exclusion chromatography, affinity chromatography, ultrafiltration, membrane filtration, etc. can be selected according to the specific requirements.

Biofunctional Activities of Laminarin

• Immune regulating activity: Enhance the specific and non-specific immune function of the body.
• Anti-tumor activity: Directly kill tumor cells, inhibit angiogenesis, induce apoptosis, and regulate immunity.
• Regulating blood lipid and blood glucose levels: Lower plasma cholesterol and reduce atherosclerotic index. Lower blood level and boost insulin production.
• Antioxidant activity: Clear reactive oxygen species, and modulate antioxidant system or signaling pathways mediated by oxidative stress.
• Anti-radiation activity: Exclude and prevent the body from absorbing radioactive elements like ⁵⁴Mn, ⁹⁰Sr, ¹⁰⁹Cd, ¹³³Sn, and ¹³³Ra.

Applications

• Development of functional food and nutraceuticals
• Excellent source of dietary fiber
• Complementary therapy to manage skin diseases
• Development anti-tumor research

Advantages

• Multiple extraction strategies for laminarin
• Optional purification methods for laminarin
• The usage of mature technologies: high-efficiency, environmental protection

CD BioGlyco offers optimized, high-quality laminarin manufacture service in a short time. We also provide other Beta-Glucan Manufacture Services, as well as relative Quantification Service, Structural Analysis Service, Fermentation Profiling Service, and Vaccine Adjuvant Development. If you have a need in our services, please contact us for detailed information.

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