Separation Process for High-Purity Oligosaccharide Manufacture
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Oligosaccharides have good solubility, high skin affinity, and no cytotoxicity, which can be safely used in medicine, health care products, functional foods, and cosmetics.
Oligosaccharides possess multiple pharmacological activities:
- Immunomodulatory effect: Oligosaccharides enhance both cellular immune functions and humoral immune functions by protecting immune organs from damage, inhibiting the apoptosis of immune cells, and promoting immune cells to produce a variety of different cytokines.
- Anti-oxidation effect: Oligosaccharides can effectively remove free radicals and toxins from the body, playing an antioxidant effect, with the capacity to be used as ingredients of functional foods.
- Anti-tumor effect: Oligosaccharides are active fragments of the biological effects of sugars, which activate the complement system by activating the immune system or enhancing the antioxidant effect, and finally show good inhibitory activity against some tumors.
- Regulate blood sugar and lipid levels: Oligosaccharides protect and repair islet beta cells, inhibit α-glucosidase activity, regulate the activity of glucokinase and glucose-6-phosphatase, and inhibit gluconeogenesis.
- Anti-infection effect: Oligosaccharides have broad-spectrum antibacterial activity by destroying the cell wall and membrane of bacteria, destroying the structure of protein and genetic material, and inhibiting respiration.
Fig.1 Pharmaceutical activities of oligosaccharides. (CD BioGlyco)
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Based on the excellent pharmacological functions, oligosaccharides have great research value and application potential. Beforehand, it is necessary to prepare oligosaccharides with high purity and a specific polymerization degree, because the performance of oligosaccharides is closely related to the purity and molecular weight. CD BioGlyco has cutting-edge high-purity oligosaccharide manufacture technologies. Our services include the following:
Fig.2 Separation process for high-purity oligosaccharide manufacture. (CD BioGlyco)
Batch chromatography is a very perfect operating unit that is frequently used at preparative and process scales. By this technology, oligosaccharide molecules with ideal purity can be obtained and high-yield preparation of target oligosaccharides will be achieved.
SMB chromatography is a kind of continuous chromatographic separation technology that can achieve large-scale production. The fixed phase utilization rate is improved, the oligosaccharide product concentration is increases, and the solvent consumption is effectively reduced.
Microbial purification technology is a competitive biotechnology, which can effectively remove impurities from oligosaccharides, reduce the cost of separating process, and expand the market of high-purity oligosaccharides.
Applications
- Mass production of oligosaccharides with high purity and specific polymerization degree
- Pharmacological activity research
- Cosmetic ingredient research
- Development of functional food
- Development of health care product
Highlights
- Sophisticated separation equipment
- Scientific and reliable production process
- Thoughtful after-sales service
If your application requires custom oligosaccharides, the highly educated expert team at CD BioGlyco will use their extensive knowledge in Oligosaccharide Manufacture to meet your needs, please contact us today for more details.
Reference
- Maráz, A.; et al. Recent developments in microbial production of high-purity galacto-oligosaccharides. World Journal of Microbiology and Biotechnology. 2022, 38: 95.
For research use only. Not
intended for any clinical use.
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